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KMID : 1103920040100030223
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Korean Journal of Hepatology
2004 Volume.10 No. 3 p.223 ~ p.227
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Mucinous Cholangiocarcinoma associated with Clonorchis sinensis Infestation: A Case Report
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심효섭/Shim HS
임범진/김명진/이우정/박찬일/박영년/Lim BJ/Kim MJ/Lee WJ/Park C/Park YN
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Abstract
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Mucinous cholangiocarcinoma, characterized by large quantities of mucin production, is a rare subtype of peripheral cholangiocarcinoma and usually shows rapid progression and a fatal outcome. We report here a case of mucinous cholangiocarcinoma in a 69 year-old man, who was infected with Clonorchis sinensis. Histologically, the tumor was an adenocarcinoma with extensive intracellular and extracellular mucin production, up to 70% of the tumor mass and there was frequent lymphovascular invasion of the tumor cells. The liver adjacent to the mass contained eggs of Clonorchis sinensis in the bile duct lumen and showed ductal epithelial hyperplasia, mucinous metaplasia and adenomatous proliferation of intramural glands. The patient was treated with a right hepatectomy. Four months after the surgery, the tumor recurred in the soft tissue of the right flank.
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